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הפקולטה למדעי החברה

ע"ש שמואל והרטה עמיר

אוניברסיטת חיפה

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אודות

My career has focused on behavioral sciences and psychology as well as neurobiology. I did my PhD at Tel-Aviv University,two post-doc terms at the Weizmann institute, and one post-doc term at the Max-Plank Institute for Psychiatry in Munich. My laboratory at the University of Haifa was established during 2017 and is studying the neural circuitry in the basis of several disorders such as OCD and PTSD , focusing on mapping the adaptive activity in the related circuits to understand the malfunctions leading to pathological symptoms

פרסומים

1. Joel, D. & Klavir, O. (2006). The effects of temporary inactivation of the orbital cortex in the signal attenuation rat model of obsessive-compulsive disorder. Behavioral Neuroscience, 120(4): 976-983. - https://psycnet.apa.org/doiLanding?doi=10.1037%2F0735-7044.120.4.976

2. Winter, C., Flash, S., Klavir, O., Klein, J., Sohr, R., and Joel, D. (2008). The role of the subthalamic nucleus in ‘compulsive’ behavior in rats. European Journal of Neuroscience, 27: 1902-11. https://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2008.06148.x

3. Faisher-Grinberg, S., Klavir, O., and Joel, D. (2008). The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive–compulsive disorder. International Journal of Neuropsychopharmacology, 11: 1-15. https://academic.oup.com/ijnp/article/11/6/811/671134?login=false

4. Klavir, O., Winter, C., Flash, S., and Joel, D. (2009). High frequency stimulation and pharmacological inactivation of the subthalamic nucleus reduces ‘compulsive’ lever-pressing in rats. Experimental Neurology, 215(1): 101-109. https://www.sciencedirect.com/science/article/abs/pii/S0014488608003701?via%3Dihub

5. Schilman, E. A., Klavir, O., Winter, C., Sohr, R., and Joel, D. (2010). The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic system. Neuropsychopharmacology, 35(4): 1026-39. https://www.nature.com/articles/npp2009208

6. Klavir, O., Winter, C., and Joel, D. (2011). High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces ‘compulsive’ lever-pressing in rats. Behavioural Brain Research, 216: 84-93. https://www.sciencedirect.com/science/article/abs/pii/S016643281000519X?via%3Dihub

7. Klavir, O., Genud-Gabai, R., and Paz, R. (2012) Low-frequency stimulation depresses the primate anterior-cingulate-cortex and prevents spontaneous recovery of aversive memories. Journal of Neuroscience, 32: 8589-8597. https://www.jneurosci.org/content/32/25/8589.long

8. Genud-Gabai, R., Klavir, O. and Paz, R. (2013) Safety signals in the primate Amygdala. Journal of Neuroscience, 33(46): 17986-17994. https://www.jneurosci.org/content/33/46/17986.long

9. Klavir, O., Genud-Gabai, R., and Paz, R. (2013) Functional connectivity between Amygdala and Cingulate-cortex for adaptive aversive learning. Neuron, 80(5): 1290-1300. (article preview by Likhtik & Gordon in the same issue). https://www.sciencedirect.com/science/article/pii/S0896627313008660

10. Klavir, O., Prigge, M., Sarel, A., Paz, R., and Yizhar, O. (2017) Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex. Nature Neuroscience, 20(6): 836-844. (article preview by Stujenske & Likhtik in the same issue). https://www.nature.com/articles/nn.4523

11. Yizhar, O. & Klavir, O. (2018) Reciprocal amygdala-prefrontal interactions in learning. Current Opinion in Neurobiology, 52: 149-155. https://www.sciencedirect.com/science/article/abs/pii/S0959438818300813?via%3Dihub

12. Bar Or, M. & Klavir, O. (2021). The Differential Effects of the Amount of Training on Sensitivity of Distinct Actions to Reward Devaluation. Brain Sciences, 11(6): 732, 17 pages. https://www.mdpi.com/2076-3425/11/6/732

13. An, S., Wang, J., Zhang, X., Duan, Y., Xu, Y., Lv, J., Wang, D., Zhang, H., Richter-Levin, G., Klavir, O., and Yu, B. (2021). αCaMKII in the lateral amygdala mediates PTSD-Like behaviors and NMDAR-Dependent LTD. Neurobiology of Stress, 15: 100359, 13 pages. https://www.sciencedirect.com/science/article/pii/S2352289521000679

14. Admon, R., & Klavir, O. (2021). Cognitive and Behavioral Patterns across Psychiatric Conditions. Brain Sciences, 11(12): 1560, 3 pages. https://www.mdpi.com/2076-3425/11/12/1560

15. Ritter, A., Habusha, S., Givon, L., Edut, S., Klavir, O. (2024). Prefrontal Control of Superior Colliculus Modulates Innate Escape Behavior Following Adversity. Nature Communications, 15(1): 2158, 16 pages. https://www.nature.com/articles/s41467-024-46460-z

16. Givon, L., Edut, S., Klavir, O. (2025). The role of fear and dopamine-striatal pathways in grooming. Neuropharmacology, 269: 110323, 12 pages. https://www.sciencedirect.com/science/article/pii/S0028390825000292

17. Hu, Z. B., Liu, W. T., Li, Y. W., Hu, L., Huang, Y., Liu, X. Y., Zhang, Q., Wang, Y. B., Chen, J. Y., Li, Z. X., Tu, S. X., Zhao, L., Song, N. N., Klavir, O & Ding, Y. Q. (2025). A rat Satb1 truncation causes neurodevelopmental abnormalities recapitulating the symptoms of patients with SATB1 mutations. Acta Pharmacologica Sinica, 1-14. https://www.nature.com/articles/s41401-025-01588-6

השכלה

PhD Psychology

רקע אקדמי

B.A. Ben Gurion University of Beer-sheva, Department of Behavioral sciences 2000-2002 M.A. Tel-Aviv University, Department of Psychology 2003-2005 Ph.D. Tel-Aviv University, Department of Psychology 2006-2010 Post doc: 2010-2012 Weizmann Institute of science, Department of Neurobiology Prof. Rony Paz 2012-2013 Weizmann Institute of science, Department of Neurobiology Prof. Ofer Yizhar 2016 Max Plank Institute for Psychiatry, Department of Stress Neurobiology and Neurogenetics Prof. Alon Chen

תחומי מחקר

https://open.spotify.com/episode/0CbCrlbIshA70yGFin2hMVhttps://glz.co.il/%D7%92%D7%9C%D7%A6/%D7%AA%D7%95%D7%9B%D7%A0%D7%99%D7%95%D7%AA/%D7%A8%D7%99%D7%A0%D7%95-%D7%A6%D7%A8%D7%95%D7%A8/%D7%A8%D7%99%D7%A0%D7%95-%D7%A6%D7%A8%D7%95%D7%A815-05-2018-1201/%D7%9C%D7%9E%D7%94-%D7%94%D7%90%D7%96%D7%A2%D7%A7%D7%95%D7%AA-%D7%9E%D7%A4%D7%97%D7%99%D7%93%D7%95%D7%AA-%D7%90%D7%95%D7%AA%D7%A0%D7%95-%D7%94%D7%97%D7%95%D7%95%D7%99%D7%94-%D7%94%D7%A8%D7%92%D7%A9%D7%99%D7%AA-%D7%A9%D7%9C-%D7%94%D7%90%D7%96%D7%A2%D7%A7%D7%95%D7%AA-%D7%9E%D7%96%D7%9B%D7%99%D7%A8%D7%94-%D7%9C%D7%A0%D7%95-%D7%A4%D7%97%D7%93https://www.jpost.com/science/article-793808